中文名稱(chēng)藤黃酸A中文同義詞藤黃酸(標(biāo)準(zhǔn)品);GAMBOGICACID藤黃酸;藤黃酸25MG;藤黃酸,一種半胱天冬酶抑制劑;藤黃酸(鑒別用);藤黃酸,97%(HPLC);藤黃酸A;藤黃酸英文名稱(chēng)GAMBOGICACID英文同義詞GaMbogicaci;BETA-GUTTIFERIN;BETA-GUTTILACTONE;GAMBOGICACID;GUTTATICACID;β-Guttilactone;Gambogicacid,95%,acaspasesactivator;2-ButenoicacChemicalbookid,2-methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-buten-1-yl)-11-(4-methyl-3-penten-1-yl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-,(2Z)-CAS號(hào)2752-65-0分子式C38H44O8分子量628.75中文名稱(chēng)藤黃酸A中文同義詞藤黃酸(標(biāo)準(zhǔn)品);GAMBOGICACID藤黃酸;藤黃酸25MG;藤黃酸,一種半胱天冬酶抑制劑;藤黃酸(鑒別用);藤黃酸,97%(HPLC);藤黃酸A;藤黃酸英文名稱(chēng)GAMBOGICACID英文同義詞GaMbogicaci;BETA-GUTTIFERIN;BETA-GUTTILACTONE;GAMBOGICACID;GUTTATICACID;β-Guttilactone;Gambogicacid,95%,acaspasesactivator;2-ButenoicacChemicalbookid,2-methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-buten-1-yl)-11-(4-methyl-3-penten-1-yl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-,(2Z)-CAS號(hào)2752-65-0分子式C38H44O8分子量628.75中文名稱(chēng)藤黃酸 A中文同義詞藤黃酸(標(biāo)準(zhǔn)品);GAMBOGIC ACID 藤黃酸;藤黃酸 25MG;藤黃酸, 一種半胱天冬酶抑制劑;藤黃酸(鑒別用);藤黃酸, 97%(HPLC);藤黃酸 A;藤黃酸英文名稱(chēng)GAMBOGIC ACID英文同義詞GaMbogic aci;BETA-GUTTIFERIN;BETA-GUTTILACTONE;GAMBOGIC ACID;GUTTATIC ACID;β-Guttilactone;Gambogic acid, 95%, a caspases activator;2-Butenoic acid, 2-methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-buten-1-yl)-11-(4-methyl-3-penten-1-yl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-, (2Z)-CAS號(hào)2752-65-0分子式C38H44O8分子量628.75名稱(chēng)藤黃酸 A中文同義詞藤黃酸(標(biāo)準(zhǔn)品);GAMBOGIC ACID 藤黃酸;藤黃酸 25MG;藤黃酸, 一種半胱天冬酶抑制劑;藤黃酸(鑒別用);藤黃酸, 97%(HPLC);藤黃酸 A;藤黃酸英文名稱(chēng)GAMBOGIC ACID英文同義詞GaMbogic aci;BETA-GUTTIFERIN;BETA-GUTTILACTONE;GAMBOGIC ACID;GUTTATIC ACID;β-Guttilactone;Gambogic acid, 95%, a caspases activator;2-Butenoic acid, 2-methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-buten-1-yl)-11-(4-methyl-3-penten-1-yl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-, (2Z)-CAS號(hào)2752-65-0分子式C38H44O8分子量628.75中文名稱(chēng)藤黃酸 A中文同義詞藤黃酸(標(biāo)準(zhǔn)品);GAMBOGIC ACID 藤黃酸;藤黃酸 25MG;藤黃酸, 一種半胱天冬酶抑制劑;藤黃酸(鑒別用);藤黃酸, 97%(HPLC);藤黃酸 A;藤黃酸英文名稱(chēng)GAMBOGIC ACID英文同義詞GaMbogic aci;BETA-GUTTIFERIN;BETA-GUTTILACTONE;GAMBOGIC ACID;GUTTATIC ACID;β-Guttilactone;Gambogic acid, 95%, a caspases activator;2-Butenoic acid, 2-methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-buten-1-yl)-11-(4-methyl-3-penten-1-yl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-, (2Z)-CAS號(hào)2752-65-0分子式C38H44O8分子量628.75

藤黃酸 A

中文名稱(chēng)藤黃酸A中文同義詞藤黃酸(標(biāo)準(zhǔn)品);GAMBOGICACID藤黃酸;藤黃酸25MG;藤黃酸,一種半胱天冬酶抑制劑;藤黃酸(鑒別用);藤黃酸,97%(HPLC);藤黃酸A;藤黃酸英文名稱(chēng)GAMBOGICACID

體外研究GambogicAcid是一種籠呫噸酮，衍生自藤黃，通過(guò)抑制人類(lèi)Bcl-2家族蛋白并活化胱天蛋白酶，在許多類(lèi)型的癌細(xì)胞中產(chǎn)生很強(qiáng)的凋亡誘導(dǎo)作用。GambogicAcid也會(huì)阻斷Kir2.1通道，EC50為≤100nM。GambogicAcid在nM濃度下顯著抑制人臍靜脈內(nèi)皮細(xì)胞(HUVEC)增殖，遷移，侵襲，血管形成，和微血管生長(zhǎng)。在動(dòng)物腫瘤模型和臨床試驗(yàn)中，GambogicAcid有效抑制腫瘤生長(zhǎng)，并且副作用很小，對(duì)免疫和造血系統(tǒng)具有低毒性。GambogicAcid能夠產(chǎn)生組織特異性蛋白酶抑制作用和腫瘤特異性毒性。LD50:小鼠45毫克/千克(腹腔注射)?；瘜W(xué)性質(zhì)黃色結(jié)晶，可溶于甲醇、乙醇、DMSO等有機(jī)溶劑，來(lái)源于藤黃的膠質(zhì)樹(shù)脂。用途藤黃酸具有抗癌的作用，對(duì)乳腺癌、淋巴瘤、皮膚癌、胃癌均有一定療效。用途用于含量測(cè)定/鑒定/藥理實(shí)驗(yàn)等。藥理藥效:具有較強(qiáng)的抗癌活性，體外對(duì)非致病性原蟲(chóng)有抑制作用。臨床研究證明，本品對(duì)乳腺癌、淋巴瘤、皮膚癌、胃癌均有一定療效，而對(duì)正常造血系統(tǒng)和白細(xì)胞無(wú)影響。類(lèi)別有毒物品毒性分級(jí)高毒急性毒性腹腔-大鼠LD50:88毫克/公斤;靜脈-小鼠LD50:107毫克/公斤可燃性危險(xiǎn)特性明火可燃;熱分解排出辛辣刺激煙霧儲(chǔ)運(yùn)特性庫(kù)房通風(fēng)低溫干燥;與食品原料分開(kāi)儲(chǔ)運(yùn)滅火劑水、泡沫、二氧化碳、干粉

藤黃酸 A