Latrepirdine97657-92-6

Latrepirdine
分子式：C21H25N3.2HCl   分子量：392.37
 
產(chǎn)品描述
Dimebon是一種抗組織胺的藥物。
靶點(diǎn)
 
 
 
     
IC50
 
 
 
     
生物活性
Latrepirdine (INN, also known as dimebolin and sold as Dimebon), is an antihistamine drug. Research is continuing in both Russia and western nations into potential applications as a neuroprotective drug to combat Alzheimer’s disease and, possibly, as a nootropic as well. However, a Phase III clinical trial for Alzheimer’s disease treatment failed to show any benefit.
Latrepirdine operates through multiple mechanisms of action, blocking the action of neurotoxic beta-amyloid proteins, inhibiting L-type calcium channels, modulating the action of AMPA and NMDA glutamate receptors, exerting a neuroprotective effect by blocking a novel target that involves mitochondrial pores, blocking a number of other receptors including α-adrenergic, 5-HT2C, 5-HT5A, and 5-HT6.
溶解性
DMSO 24 mg/mL，水 79 mg/mL，乙醇 13 mg/mL
穩(wěn)定性
2年 -20°C粉狀，6月-80°C溶于DMSO