(R)-baclofen 69308-37-8

(R)-baclofen
分子式：C10H12ClNO2   分子量：213.66
 
產(chǎn)品描述
(R)-baclofen是一種γ-氨基丁酸衍生物，主要用于治療痙攣。
靶點(diǎn)
           
IC50
           
體外研究
Baclofen is a skeletal muscle relaxant used in the treatment of spasticity of spinal and cerebral origin. Although it is marketed as a racemic mixture, only the baclofen R-enantiomer is stereospecifically active at so called GAGAB-receptors. Researchers believe that the enantiomers of baclofen have different properties. It is claimed that the R-(−)-enantiomer is about 100 times more active than the S-(+)-enantiomer.
體內(nèi)研究
 
溶解性
DMSO <1 mg/mL，水 8 mg/mL，乙醇 <1 mg/mL
穩(wěn)定性
2年 -20°C粉狀，6月-80°C溶于DMSO