DNA-PK Inhibitor V(AMA37)404009-46-7

DNA-PK Inhibitor V(AMA37)
分子式：C17H17NO3   分子量：283.3
 
產(chǎn)品描述
DNA-PK Inhibitor V(AMA37)是一種嗎啉代苯甲酮、ATP競(jìng)爭(zhēng)性DNA-PK抑制劑。
靶點(diǎn)
 
        
IC50
 
        
生物活性
A morpholino-benzophenone compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of DNA-PK (IC50 = 270 nM). Inhibits PI 3-K catalytic subunit p110-isozymes at higher concentrations (IC50 = 32 µM, 3.7 µM, 22 µM and ~ 100 µM for α, β, δ and γ, respectively) and weakly inhibits a panel of several other kinases, including, ATM, ATR, CK2, GRK2, mTOR, PI 3KC2α, PI 3KC2β, PI 3KC2γ and PI 4Kβ, even at concentrations as high as 50 µM.
溶解性
可溶于DMSO
穩(wěn)定性
2年 -20°C粉狀，6月-80°C溶于DMSO