Nitrendipine39562-70-4 尼群地平

尼群地平
分子式：C18H20N2O6    分子量：360.36
 
 
 
產(chǎn)品描述
Nitrendipine是一種二氫吡啶類鈣離子通道抑制劑，IC50為95 nM。
生物活性
Nitrendipine is a dihydropyridine calcium channel blocker with an IC50 of 95 nM.It is an investigational dihydropyridine calcium-channel antagonist for the treatment of hypertension. Nitrendipine and BRL 38227 cause concentration-related inhibitions of the inositol phosphate response to histamine (100 µM). Similar maximal inhibitions were caused by each agent (55-58%). Inhibitory effect of BRL 38227 was reduced in potency (IC50 = 5.5 µM), but not magnitude, in the presence of glibenclamide (0.5 µM).
溶解性
DMSO 72 mg/mL，水 <1 mg/mL，乙醇 <1 mg/mL
穩(wěn)定性
2年 -20°C粉狀，6月-80°C溶于DMSO